Is SAMe supplementation for depression known to cause sexual dysfunction?

No. Un- or under-treated depression can do that and many Rx medications too, but this is not reported as a SAMe side effect. http://preview.tinyurl.com/oqodvhv Are your depression symptoms well relieved? If not and if you want to avoid Rx - try CBT therapy to learn skills to manage symptoms - it may optimize the SAMe and also address sexual concerns. Best!