Doez Prazosin cross the BBB and work in the CNS? I've read conflicting things on pubmed and elsewhere. Does any alpha-1 blocker cross the BBB?

You must be reading. about its use as it treats nightmares in the brain. So yes, it clearly crosses the BBB and clearly WORKS. I treat many people with PTSD and nightmares from war vets to civilians, rape victims, assault, other abuse victims who have terrible nightmares and it practically clears everything up inside of 1 week or 2. Problems are lowered blood pressure, allergic reactions, and, first dose syncope.