4 doctors weighed in:

What narcotic pain medication will not metabolize in the liver?

4 doctors weighed in
Dr. Peter Kurzweil
Internal Medicine
3 doctors agree

In brief: None,at least partly

Most drugs are metabolized in the liver or kidney, but almost all a combination of both.
It is the proportion metabolized in one or other that varies. Alsoimpish liver, it is key to know which enzyme system metabolizes which drug, to understand what interaction one drug will have on another. A most important example is Coumadin (warfarin). Narcotics, as a family of drugs-mostly liver.

In brief: None,at least partly

Most drugs are metabolized in the liver or kidney, but almost all a combination of both.
It is the proportion metabolized in one or other that varies. Alsoimpish liver, it is key to know which enzyme system metabolizes which drug, to understand what interaction one drug will have on another. A most important example is Coumadin (warfarin). Narcotics, as a family of drugs-mostly liver.
Dr. Peter Kurzweil
Dr. Peter Kurzweil
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