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How will botulism cause muscle paralysis?

1 doctor weighed in
Dr. Gael Yonnet
Neurology

In brief: See answer below

Botulinum neurotoxins essentially prevent the release of acetylcholine (neurotransmitter) in the synaptic cleft, thus preventing the trigger of muscle contraction.
The paralysis in the skeletal muscle lasts for about 3 months. It lasts up to 9-12 months if used in the detrusor muscle in the bladder. Strength eventually returns when new connections are created between the nerves and the muscles.

In brief: See answer below

Botulinum neurotoxins essentially prevent the release of acetylcholine (neurotransmitter) in the synaptic cleft, thus preventing the trigger of muscle contraction.
The paralysis in the skeletal muscle lasts for about 3 months. It lasts up to 9-12 months if used in the detrusor muscle in the bladder. Strength eventually returns when new connections are created between the nerves and the muscles.
Dr. Gael Yonnet
Dr. Gael Yonnet
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