3 doctors weighed in:

If on irinotecan since oct CEA is rising as Dec-9 Jan- 10 Does this mean chemo not working?it was 8 in October It was 8 before in October

3 doctors weighed in
Dr. Myron Arlen
Surgery - Oncology

In brief: Progression disease

Irinotecan (Camptosar (irinotecan) ) is a drug used for the treatment of cancer.
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In clinical trials it is used for metastatic tumor such as colon Ca. The CEA acting as a tumor marker is only of value in monitoring response to treatment so that elevation means growing tumor. Diagnosis cant be made by presence of CEA in serum.

In brief: Progression disease

Irinotecan (Camptosar (irinotecan) ) is a drug used for the treatment of cancer.
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In clinical trials it is used for metastatic tumor such as colon Ca. The CEA acting as a tumor marker is only of value in monitoring response to treatment so that elevation means growing tumor. Diagnosis cant be made by presence of CEA in serum.
Dr. Myron Arlen
Dr. Myron Arlen
Thank
Dr. Sewa Legha
Internal Medicine - Oncology

In brief: Give us serial CEAs

CEA is not an entirely reliable tumor marker unless it is high(>10 ng) and it is steadily rising on 3-4 tests done about 4-6 weeks apart.
Give us this information from the last 3-4 months, then we can help you. Also tell us your diagnosis.

In brief: Give us serial CEAs

CEA is not an entirely reliable tumor marker unless it is high(>10 ng) and it is steadily rising on 3-4 tests done about 4-6 weeks apart.
Give us this information from the last 3-4 months, then we can help you. Also tell us your diagnosis.
Dr. Sewa Legha
Dr. Sewa Legha
Thank
Dr. Forrest Jones
Family Medicine

In brief: See your oncologist

From a PubMed reference: "A CEA surge can be induced by irinotecan-based chemotherapy.
An early increase in CEA after irinotecan-based chemotherapy does not usually indicate progression of disease and failure of therapy, and should not lead to a change of chemotherapy." Whether this is relevant to your case can best be determined when you talk it over with your oncologist. Hope that helps.

In brief: See your oncologist

From a PubMed reference: "A CEA surge can be induced by irinotecan-based chemotherapy.
An early increase in CEA after irinotecan-based chemotherapy does not usually indicate progression of disease and failure of therapy, and should not lead to a change of chemotherapy." Whether this is relevant to your case can best be determined when you talk it over with your oncologist. Hope that helps.
Dr. Forrest Jones
Dr. Forrest Jones
Thank
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