9 doctors weighed in:
Will there be a Zoloft (sertraline) and metoprolol tartrate interaction?
9 doctors weighed in

Mazin Albert
General Practice
5 doctors agree
In brief: Possible
Sertraline, brand name zoloft, (sertraline) can increase the level or effect of metoprolol by affecting the hepatic enzyme cyp2d6 metabolism but only above 150mg/day.
You may need a lower dose of metoprolol to compensate. More important is that metoprolol, blocks Adrenalin and gets into the brain, possibly causing worse depression, fatigue and concentration problems. Don't worry unless you note a problem.

In brief: Possible
Sertraline, brand name zoloft, (sertraline) can increase the level or effect of metoprolol by affecting the hepatic enzyme cyp2d6 metabolism but only above 150mg/day.
You may need a lower dose of metoprolol to compensate. More important is that metoprolol, blocks Adrenalin and gets into the brain, possibly causing worse depression, fatigue and concentration problems. Don't worry unless you note a problem.
Mazin Albert
Mazin Albert
Answer assisted by Mazin Albert, Medical Student
Thank
Dr. Marc Zimmermann
Psychiatry
5 doctors agree
In brief: Possibly
Sertraline may potentiate the effect of metoprolol.
It may cause the heart to beat at a slower rate than normal. Symptoms of this condition include dizziness, chest pain, and fainting.

In brief: Possibly
Sertraline may potentiate the effect of metoprolol.
It may cause the heart to beat at a slower rate than normal. Symptoms of this condition include dizziness, chest pain, and fainting.
Dr. Marc Zimmermann
Dr. Marc Zimmermann
Thank
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