Recently diagnosed with myasthenia gravis and about to start mestinon (pyridostigmine). What do I need to know?
Symptom treatment. While myasthenia reduces the effectiveness of muscle activation, Mestinon (pyridostigmine) works to increase it. It works well and starts working quickly, but does not change the course of the underlying disease- typically an immune modifying drug is used in conjunction with it to prevent disease progression. Typical side effects include diarrhea, abdominal cramping, and muscle twitches.
Mestinon (pyridostigmine) dose. You need to know if what is the best dose (1/2 tab, 1 tab or 11/2 tab) for you and how long it works. Low dose may not be effective and high dose may give to side effects like colic and increase secretions.
Recently diagnosed with myasthenia gravis and about to start mestinon (pyridostigmine). Is it a powerful medicine?
No. Mestinon (pyridostigmine) helps to restore some of the strength you lose in myesthenia gravis. It inhibits the breakdown of the chemical your body makes and you need to let muscles contract. You are given only a dose that helps to do this, not more.
Not long ago diagnosed with myasthenia gravis and about to start mestinon (pyridostigmine). please help!?
Take Med. Take the mestinon (pyridostigmine) and see a good neurologist. Myasthenia is caused by an antibody that attacks the acetylcholine receptors on muscle tissue and leads to weakness. Mestinon (pyridostigmine) will help, but you need an expert to help care for your condition.
See below. In myesthenia gravis, the body produces antibodies to the a type of muscle receptor that uses acetylcholine, a neurotransmitter responsible for muscle contraction. These antibodies prevent electrical signals from getting to the muscles which causes weakness. Mestinon (pyridostigmine) slows down the breakdown of acetylcholine in the body so that more acetylcholine is around to interact with the receptors.
Activate muscle. Myasthenia disrupts the connection between nerve and muscle by reducing the number of receptors for a transmitter called acetylcholine. Mestinon (pyridostigmine) prevents acetylcholine from being broken down in the body, giving it more time to diffuse along the muscle and activate the remaining receptors. The net result is to restore effective transmission between nerve and muscle.
My left eye droops, and diagnosed as myasthenia gravis, but still droops on mestinon (pyridostigmine)?
Possible. First thing we need to know, how certain is the diagnosis? Was it established by blood tests, tensilon test, biopsy? If diagnosis is assuredly myesthenia gravis (mg), it is still possible for the ocular symptoms (droopy lid, double vision) to fail to respond to mestinon (pyridostigmine). See a specialist eye md (neuro-ophthalmologist) to decide if a higher dose of mestinon (pyridostigmine), steroids, or thymus surgery may help.
Are there any new treatments for myasthenia gravis rather than the traditional cortisone and mestinon (pyridostigmine) or thymectomy?
Not really. Those are the tested ones.
My husband is taking mestinon, (pyridostigmine) methotrexate, and prednisone for myasthenia gravis. Are all 3 needed?
See below. Myesthenia gravis is an autoimmune disease. That means that the body produces antibodies that attack normal tissue. In the case of mg, the antibodies attack the receptor that chemically links the nerves to the muscles. The Mestinon (pyridostigmine) improves nerve transmission so the muscles work better. The Methotrexate and Prednisone suppress the production of antibodies that attack the receptors.
Quite possibly. About 1/3 can see spontaneous remission, 1/3 stabilize on chronic medications, and 1/3 have progressive difficulties. In appropriate candidates, minimally invasive thoracic surgery to remove thymus (thymectomy) can possibly cure or stabilize disease or decrease amount and/or types of meds. This link may help: http://goo. Gl/3xxmd.
NO, NOT AT ALL. Mestinon (pyridostigmine) enhances neuromuscular junctional efficiency by enhancing acetylcholine persistence, but is NOT an immune agent like a steroid. The standard testing for myasthenia gravis looks at antibody reactions, and would be positive or negative irregardless of use of Mestinon (pyridostigmine).
Synaptic cleft. Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine, what ultimately improves the strength of the muscle.
????? Pyridostigmine is the standard treatment for myasthenia gravis and 60 mg is a standard dose. What is your question?