Can I have a glass of wine if I'm taking 500mg of amoxicillin for a tooth infection?

1glass only! Alcoholic beverages, including wine often reduce the effectiveness of medications. For your own well being, try to abstain, but one glass would probably be ok.
Not recommended. There is a common myth that alcohol mixed with antibiotics, such as amoxicillin, causes interactions. Because of the delay of the healing process alcohol is not recommended. Drink a lot of water and get well soon.