6 doctors weighed in:

How would liver dysfunction cause bleeding disorders?

6 doctors weighed in
Dr. Susumu Inoue
Pediatrics - Hematology & Oncology
3 doctors agree

In brief: Liver makes clotting

The liver makes most of the proteins that make blood clot.
Thus dysfunction of the liver results in deficiency of many clotting proteins leading to bleeding tendency. Another reason is that the liver converts inactive form of some of the clotting factors to active forms with the help of vitamin k. The liver dysfunction can not make this conversion fully, and thus bleeding tendency.

In brief: Liver makes clotting

The liver makes most of the proteins that make blood clot.
Thus dysfunction of the liver results in deficiency of many clotting proteins leading to bleeding tendency. Another reason is that the liver converts inactive form of some of the clotting factors to active forms with the help of vitamin k. The liver dysfunction can not make this conversion fully, and thus bleeding tendency.
Dr. Susumu Inoue
Dr. Susumu Inoue
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Dr. Kelty Baker
Internal Medicine - Hematology
2 doctors agree

In brief: Liver and bleeding

The liver makes almost all clotting factors which prevent bleeding.
When the liver isn't working correctly, these factors become low and the blood becomes "too thin". Also, liver disease causes an enlarged spleen and an enlarged spleen causes low platelets, the blood cells which are important in the early phases of blood coagulation. People with low platelets (thrombocytopenia) bleed easily.

In brief: Liver and bleeding

The liver makes almost all clotting factors which prevent bleeding.
When the liver isn't working correctly, these factors become low and the blood becomes "too thin". Also, liver disease causes an enlarged spleen and an enlarged spleen causes low platelets, the blood cells which are important in the early phases of blood coagulation. People with low platelets (thrombocytopenia) bleed easily.
Dr. Kelty Baker
Dr. Kelty Baker
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