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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

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Dr. Myron Arlen
Surgery - Oncology

In brief: Genetic mutations

HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach.
The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca.

In brief: Genetic mutations

HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach.
The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca.
Dr. Myron Arlen
Dr. Myron Arlen
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