5 doctors weighed in:

Why is demeclocycline (declomycin) given for SIADH?

5 doctors weighed in
Dr. Alan Ali
Psychiatry
3 doctors agree

In brief: Demeclocycline

It induces nephrogenic diabetes insipidus (dehydration due to inability to concentrate urine by the kidneys) as a side-effect, hence relieves the low sodium problem in SIADH.

In brief: Demeclocycline

It induces nephrogenic diabetes insipidus (dehydration due to inability to concentrate urine by the kidneys) as a side-effect, hence relieves the low sodium problem in SIADH.
Dr. Alan Ali
Dr. Alan Ali
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Dr. Charles Turck
Pharmacology

In brief: Rising sodium levels

Demeclocycline causes sodium (salt) levels in the blood to increase more slowly than something like fluids rich in sodium. That is important because if the sodium levels are being corrected too quickly, then there could be severe complications.

In brief: Rising sodium levels

Demeclocycline causes sodium (salt) levels in the blood to increase more slowly than something like fluids rich in sodium. That is important because if the sodium levels are being corrected too quickly, then there could be severe complications.
Dr. Charles Turck
Dr. Charles Turck
Thank
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