Why is a biopsy more reliable for diagnosing bladder cancer than a urine cytology?

More info in biopsy. Urine cytology examines single cells that are shed from the bladder lining and are suspended in fluid. Nuclear features of each cell can be evaluated but low grade cancer may look similar to reactive changes. A biopsy is a whole piece of tissue. The entire thickness of the lining and overall morphology can be evaluated. A biopsy is far better than urine cytology, especially for low grade lesion.

Related Questions

Can someone explain to me how come a biopsy is more reliable in diagnosing bladder cancer than a urine cytology?

Both are good. Urine cytology just catches whatever cells have broken off the tumor and ended up in the urine. These cells were usually dead to begin with, or they would not have fallen off. If they were not dead to begin with, they still die once they break off the main tumor. So the pathologist has to try to guess what type of tumor the cell came from, even though it is basically dead and rotten. Read more...
See below. Urine cytology is looking for cancer cells in the urine, which can be missed as they may not be shed into the bladder, from its lining. The amount shed may also be too small to detect. The biopsy of a suspicious area is more reliable. Read more...

Why is bladder cancer cytology positive and HPV negative?

Not related. Hpv or human papilloma virus is associated with many cancers : cervical, throat, mouth, anal, & maybe lung. It is not known to be assocaited with bladder cancer. If bladder washings or bladder cytology (kind of like a pap smear for the bladder) then cystoscopy (visual inspection of the bladder lining) and biopsy are needed. Read more...
Bladder ca. You can have bladder cancer, which can causes cancer cells to appear in urine, which means positive cytology....But this has nothing to do with testing for human papilloma virus....Two fpdifferent diseases... Read more...
Different issues. Hpv infection has not been shown to cause bladder cancer, therefore bladder/urine cytology and hpv infection are unrelated. Read more...

Other than a biopsy, is there another way to see if someone has bladder cancer?

Bladder cancer. There are highly suggestive findings such as blood or imaging, but ultimately the definitive diagnosis upon which treatment can be planned requires cytology or exam of suspicious tissue by the pathologist. Cancer is not just cancer. Treatments are planned based on the type of cells that have become malignant or invasive. Read more...
Yes, FISH testing. FISH stands for florescence in situ hybridization. The urine cells may be tested for abnormal chromosomal or genetic patterns that could indicate malignancy. Consult a urologist. Thanks for trusting HealthTap! Read more...

Dad had bladder cancer biopsy. Waiting pathology report. Dr said fairly large tumor and a few satellite tumors. Is this bad news?

Yes. Yes. A person who has a large bladder cancer with satellite tumors has a serious health problem. This can almost never be treated by putting medicine into the bladder. It usually requires surgery and/or radiation therapy and/or chemotherapy, Bladder cancer is not hereditary. The most common cause in the United States is cigarette smoking. . Read more...
Possibly. You must realize, it is very tough to guess what may be wrong. Worry will cause you anxiety and make you feel horrible. Best to wait and see what the biopsy shows, then if it is bad news, tackle the issue with a strong positive attitude. Best wishes to dad. Read more...
Need studies. The severity of bladder cancers depend on several factors. Can the tumors be removed without removing the entire bladder? Do they extend through the bladder wall? Do they extend beyond the bladder to lymph nodes or more distant sites? How immature are the tumor cells? The pathology report and CT and/or MRI studies will tell us. Then, the treatment and the long term outlook can be stated. Read more...

Is bloody urine a sign that bladder cancer has penetrated the wall of the bladder?

No. The amount of blood seen in the urine does not correlate with the degree of tumor invasion into the bladder muscle. The gold standard to determine the extent of invasion into the bladder muscle is to perform a special biopsy and evaluate for muscle invasion. One can have a little bleeding in the urine with a lot of muscle invasion or a lot of bleeding without muscle invasion. Read more...
Bloody urine. Not really. Superficial papillary tumors often bleed more than invasive tumors. Read more...

Urine test checks for bladder cancer or other problems?

Can be both. Many tests can be run on urine, although the selection is not as vast as blood testing. The basic test is called a urinalysis or ua. A urine cytology is a separate test where a pathologist evaluates the urine for cancer cells. Please ask your doctor more about the testing. Read more...
Mostly other . Problems. Urine examination can be used to diagnose bladder cancer, but urinalysis is used far more often for other issues, e.g., urinary infection, metabolic diseases like diabetes etc. See this site for more info. http://www.webmd.com/a-to-z-guides/urine-test. Read more...