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Why do tricyclic antidepressants prevent migraines?

2 doctors weighed in
1 doctor agrees

In brief: Serotonin modulation

An excellent question.
Amitriptyline affects multiple neurotransmitters, and it is believed that its modulation of serotonin calms the nerves that stimulate migraines.

In brief: Serotonin modulation

An excellent question.
Amitriptyline affects multiple neurotransmitters, and it is believed that its modulation of serotonin calms the nerves that stimulate migraines.
Dr. Alan Koenigsberg
Dr. Alan Koenigsberg
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