When do side effects of doryx (doxycycline) occur and will my body eventually adjust?

Immidiately. If you are among the unlucky ones that suffer side effects from this med, it will start within the first dose of the drug. On the other hand, if you are already taking the medicine and not feeling anything out of ordinary, then you are among the lucky ones that do not have side effects from the medicine - don't look for one, it's not fun to have them.