Is taking Benadryl (diphenhydramine) with codeine safe?

Benadryl (diphenhydramine) & Codeine. Hello. Benadryl (diphenhydramine) and codeine taken together could make you sleepy so please make sure that you are not driving, operating equipment, or involved in any activities which require your cognition to be 100% on point! Are you taking Benadryl (diphenhydramine) to counteract itching from codeine? If so, you may need to talk to your provider about trying something different.