6 doctors weighed in:
What is the actual cause of B12 (cyanocobalamin) deficiency in the body in pernicious anemia?
6 doctors weighed in

Dr. Ritesh Rathore
Internal Medicine - Hematology & Oncology
5 doctors agree
In brief: No intrinsic factor
B12 in the diet usually binds to intrinsic factor in the stomach and then gets absorbed by the small bowel.
In pernicious anemia, there is low or no intrinsic factor being made by the stomach cells. As a result, there is gradual deficit of B12 stores and eventaully as all the B12 is gone the new red blood cell production is affected.

In brief: No intrinsic factor
B12 in the diet usually binds to intrinsic factor in the stomach and then gets absorbed by the small bowel.
In pernicious anemia, there is low or no intrinsic factor being made by the stomach cells. As a result, there is gradual deficit of B12 stores and eventaully as all the B12 is gone the new red blood cell production is affected.
Dr. Ritesh Rathore
Dr. Ritesh Rathore
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