Harder with each one
Although exceptions occur and the patient's underlying health also alters outcomes, the avg live donor kidney txp lasts 15-17 years, and the avg deceased donor kidney txp lasts 10-12 years.
It is common for a pt with good health habits to outlive the kidney txp and seek another. If the pt has made antibodies to a prior donor, matching is harder. As many as 5 txps in 1 pt have been done.