Is cipro (ciprofloxacin) safe to use with patients with afib?

Maybe. as long as you're not on any other meds that interact with cipro (ciprofloxacin) .
Safety. By itself Cipro (ciprofloxacin) should not affect your heart condition. Cipro (ciprofloxacin) may interfere with some of the other drugs used to treat A fib, specifically blood thinners and drugs used to control the cardiac rhythm.