My daughter has had a fever past 48 hours with cough and slight runny nose. Ibuprofen brings it down from 102.4 to 100.4 but when should I call doc?

Now. After having fever for more than twenty four hours I always recommend the child to be seen. Your daughter should be seen now, please do not wait it has been long enough.
If lethargic. Fever can make you feel awful. As long as the child is drinking, keeping food/fluids down, and the fever is responding to medicine, keep doing what you are doing. If the fever isn't gone by tomorrow night, or if she gets "worse", she should be seen. As long as she doesn't deteriorate badly, it can probably wait till tuesday morning.