Never taken antidepressants but tested + for tca. I take prescribed Vyvanse (lisdexamfetamine) & an OTC diphenhydramine sleep aid ONLY. Can either have lead to a false +?

Benadryl (diphenhydramine) . If you do not take any tricyclic antidepressants, and have a positive TCA on a toxicology screen, is likely the diphenhydramine that you're taking, which can sometimes give a false positive for TCA. If the Vyvanse (lisdexamfetamine) hinders your nighttime sleep, consider taking melatonin rather than diphenhydramine for long-term use.