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What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

1 doctor weighed in
Dr. Martin Rubenstein
Internal Medicine - Hematology & Oncology

In brief: No simple answer.

t-cell receptor studies prove clonality, meaning an expansion of a single line of T-cells, a kind of immune system cell.
The test is mainly used to confirm the presence of T-cell cancers, but is not sufficient for cancer diagnosis because it's too sensitive and not specific. Anything that stimulates the immune system, infections, autoimmune diseases, inflammatory states, will produce a positive.

In brief: No simple answer.

t-cell receptor studies prove clonality, meaning an expansion of a single line of T-cells, a kind of immune system cell.
The test is mainly used to confirm the presence of T-cell cancers, but is not sufficient for cancer diagnosis because it's too sensitive and not specific. Anything that stimulates the immune system, infections, autoimmune diseases, inflammatory states, will produce a positive.
Dr. Martin Rubenstein
Dr. Martin Rubenstein
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