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What is a transfusion reaction?

4 doctors weighed in
1 doctor agrees

In brief: Immunologic or not

Causes for transfusion reactions may be immune related or not, also they can be acute (less than 24 hours) or delayed.
These are some: hemolytic; febrile, non-hemolytic; bacterial contamination (septic shock); anaphylaxis; transfusion-related acute lung injury (trali); transfusion-associated circulatory overload (taco); graft vs. Host disease (ta-gvhd); iron overload; infections.

In brief: Immunologic or not

Causes for transfusion reactions may be immune related or not, also they can be acute (less than 24 hours) or delayed.
These are some: hemolytic; febrile, non-hemolytic; bacterial contamination (septic shock); anaphylaxis; transfusion-related acute lung injury (trali); transfusion-associated circulatory overload (taco); graft vs. Host disease (ta-gvhd); iron overload; infections.
Dr. Juan Merayo-Rodriguez
Dr. Juan Merayo-Rodriguez
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Dr. Joseph Woods
Pathology
1 doctor agrees

In brief: Antibody-Ag reaction

A transfusion reaction is a reaction between donor RBC (red blood cell) antigens introduced into a recipient which has antibodies to at least one of these antigens.
Depending on the antigen, the reaction can be mild. Moderate, or severe. A classic example is an rh reaction, where rh positive blood is given to rh negative recipient. This can be a mistake or in massive transfusion.

In brief: Antibody-Ag reaction

A transfusion reaction is a reaction between donor RBC (red blood cell) antigens introduced into a recipient which has antibodies to at least one of these antigens.
Depending on the antigen, the reaction can be mild. Moderate, or severe. A classic example is an rh reaction, where rh positive blood is given to rh negative recipient. This can be a mistake or in massive transfusion.
Dr. Joseph Woods
Dr. Joseph Woods
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