What is the cause of polycystic kidney disease?

Cause- unknown. Exact etiology for PKD unknown. Some researchers swear that genetics plays a big role-- hence ADPKD and ARPKD ( autosomal dominant type and recessive type). But then there are other tapers not genetically oriented. Some hypothesize-- something goes wrong in signaling at cellular level during renal development--- pronephro/ mesonephros/ metabephros stages!