What difference is there between glyburide and glimepiride medications?

Diabetes. Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other. More important - you need to take control of your eating habits, your weight (if overweight), and your exercise. Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose.