2 doctors weighed in:

What difference is there between glyburide and glimepiride medications?

2 doctors weighed in
Dr. Thomas Knecht
Internal Medicine - Endocrinology
1 doctor agrees

In brief: Same family

Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation.
They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs.

In brief: Same family

Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation.
They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs.
Dr. Thomas Knecht
Dr. Thomas Knecht
Thank
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