What is the treatment for oxymetazoline overdose?

Steroids. The immediate cessation of the nasal spray and the use of oral steroid for several weeks may reverse this condition known as rhinitis medicamentosa. The main thing to do once this condition, hopefully is reversed, is to obtain a specific diagnosis such as nasal allergy or hypertrophy (enlargement) of the inferior turbinates. Surgery to reduce the size of the inferior turbinates may be curative.