Right above my groin, one side seems swollen, looks different than other side. Can jock itch cause my groin lymph nodes to swell? Or is it Cancer?

Possible hernia. More than likely, swelling in this area above the groin crease could be an inguinal hernia. Jock itch should not cause lymphatic swelling unless you have a secondary bacterial infection from an area of excoriation. See a general surgeon to get checked for a hernia.