9 doctors weighed in:

What are the tests for sjogren's syndrome?

9 doctors weighed in
Dr. Robert Lowe
Pediatric Rheumatology
4 doctors agree

In brief: A few tests

Generally, checking labs is helpful since patients with sjogren's almost always have one of two autoantibodies (ssa, ssb) present.
Ssa, ssb also present in lupus but when only ssa or ssb is pos, sjogren's is a top consideration. Doctors can also test for sicca symptoms(decreased tear production with a paper strip put on lower eye lid.Most definitive test is minor salivary gland biopsy from lip.

In brief: A few tests

Generally, checking labs is helpful since patients with sjogren's almost always have one of two autoantibodies (ssa, ssb) present.
Ssa, ssb also present in lupus but when only ssa or ssb is pos, sjogren's is a top consideration. Doctors can also test for sicca symptoms(decreased tear production with a paper strip put on lower eye lid.Most definitive test is minor salivary gland biopsy from lip.
Dr. Robert Lowe
Dr. Robert Lowe
Thank
Dr. Stanley Alexander
Internal Medicine - Rheumatology
2 doctors agree

In brief: Inflammatory markers

One screens for systemic inflammation - esr, CRP - plus immunologic markers.
Latter includes an ANA test (usually positive in most, with speckled pattern), blood complement levels (for activity), and sjogren's tests (ssa and ssb) are often helpful - positive in about 2/3. Also may require opthalmologic evaluation for dryness or damage and sometimes a biopsy or the oral mucoal glands can help.

In brief: Inflammatory markers

One screens for systemic inflammation - esr, CRP - plus immunologic markers.
Latter includes an ANA test (usually positive in most, with speckled pattern), blood complement levels (for activity), and sjogren's tests (ssa and ssb) are often helpful - positive in about 2/3. Also may require opthalmologic evaluation for dryness or damage and sometimes a biopsy or the oral mucoal glands can help.
Dr. Stanley Alexander
Dr. Stanley Alexander
Thank
3 comments
Dr. Ronald Krauser
Inflammatory markers are often normal in Sjogren's. Serum complements are normal.
Dr. Tracy Lovell
minor salivary gland biopsies are performed when sjogren labs are negative
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