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What is the fluid deprivation test for diabetes insipidus?
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Dr. Joseph Woods
Pathology
In brief: Vasopressin test.
This is a dehydration test for diabetes insipidus.
First, fluid is withheld until urine osmolality is stable. Then 5 u of vasopressin is given by subcutaneous injection. The urine and plasma osmolality/concentration is measures before and one hour after the injection. Argenine vasopressin or avp given to these patients causes a >9% rise in urine osmolality. In normal patients, it is <9%.

In brief: Vasopressin test.
This is a dehydration test for diabetes insipidus.
First, fluid is withheld until urine osmolality is stable. Then 5 u of vasopressin is given by subcutaneous injection. The urine and plasma osmolality/concentration is measures before and one hour after the injection. Argenine vasopressin or avp given to these patients causes a >9% rise in urine osmolality. In normal patients, it is <9%.
Dr. Joseph Woods
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