Will the biopsy test be big or near the site of the melanoma?

See full answer. Unless the lesion is relatively big (greater than 1/2 inch), the dermatologist will usually numb it and then do a shave biopsy to remove it. Bigger lesions usually have small ares biopsied.
Size of mole. A biopsy's size is related to the size of the original mole that is being tested, and will be located at the same place.