4 doctors weighed in:
Can I have celiac if the blood and gene tests were positive, but biopsy was negative?
4 doctors weighed in

Dr. Charles Cattano
Internal Medicine - Gastroenterology
3 doctors agree
In brief: Yes, you can
Celiac disease often presents in the small bowel as "patchy" so biopsies of only one area may not be representative.
Also, if you have celiac disease but eliminated gluten long enough for classic villous blunting changes in the small bowel to have resolved, then biopsies will look normal & the disease may be missed. Talk to your doctor about definitive diagnostic criteria for your piece-of-mind.

In brief: Yes, you can
Celiac disease often presents in the small bowel as "patchy" so biopsies of only one area may not be representative.
Also, if you have celiac disease but eliminated gluten long enough for classic villous blunting changes in the small bowel to have resolved, then biopsies will look normal & the disease may be missed. Talk to your doctor about definitive diagnostic criteria for your piece-of-mind.
Dr. Charles Cattano
Dr. Charles Cattano
Thank
Get help from a real doctor now
Dr. Adam Levy
Board Certified, Obstetrics & Gynecology
33 years in practice
1M people helped
Continue
108,000 doctors available
Read more answers from doctors