4 doctors weighed in:

Can I have celiac if the blood and gene tests were positive, but biopsy was negative?

4 doctors weighed in
Dr. Charles Cattano
Internal Medicine - Gastroenterology
3 doctors agree

In brief: Yes, you can

Celiac disease often presents in the small bowel as "patchy" so biopsies of only one area may not be representative.
Also, if you have celiac disease but eliminated gluten long enough for classic villous blunting changes in the small bowel to have resolved, then biopsies will look normal & the disease may be missed. Talk to your doctor about definitive diagnostic criteria for your piece-of-mind.

In brief: Yes, you can

Celiac disease often presents in the small bowel as "patchy" so biopsies of only one area may not be representative.
Also, if you have celiac disease but eliminated gluten long enough for classic villous blunting changes in the small bowel to have resolved, then biopsies will look normal & the disease may be missed. Talk to your doctor about definitive diagnostic criteria for your piece-of-mind.
Dr. Charles Cattano
Dr. Charles Cattano
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