How can I alleviate severe leg pain that lasts all day and all night?

Ortho Evaluation now. Leg pain that is 24/7 requires a thorough evaluation by an orthopaedic surgeon. Stress injury of the tibia, or stress fracture can cause leg pain. Soft tissue issues such as a vascular injury, blood clot, or muscle/tendon injury can also cause leg pain. X-rays, and even an MRI may help figure out the cause of your pain if not obvious upon initial examination and hearing your story.