Avoid it. I have NOT used it for MS literally for years, as it can cause a vacuolar cardiomyopathy, and acute myelocytic leukemia. It is approved by FDA for secondary progressive MS, and is the sole drug approved for this indication, but as noted, is highly risky. Not convinced that it ever helped any of my patients with SPMS. Would find alternative treatments if this choice is presented.
See answer below. Novantrone is used in patients with both relapsing-remitting and secondary progressive ms. It is a second line agent, after other agents failed to benefit the patient. It reduces the frequency of relapses and delays disease progression. Routine echocardiograms need to be obtained prior to each infusion. Infusions are administered every 3 months and limited to 8-9 infusions per lifetime.