What is/are the best test (s) for detecting a monoclonal plasma cell disorder? How sensitive are these tests? Which types of mpcds can they detect?

SPEP. The best test is a serum protein electrophoresis. It is very sensitive and specific. The disease is rare in anyone under the age of 40. For the vast majority of people the disease does not progress for many years 10-20+ so there is no role for screening.