I'm ADPKD stage 3 renal failure, severe neuropathy (neck-down) daily Cymbalta (duloxetine) 60mg & last 10days Amitryptiline 50mg. Feel agitated, paranoid. Thanks.

See provider. Please consider seeing your health care provider to check for worsening kidney function or other metabloic abnormalities are present and to see if adjusting your medicine is appropriate.