Anti-Leukemic Drugs. Anthracyclines like Daunorubicin or Idarubicin are frequently used with ara-c as part of initial (induction) therapy for acute myeloid leukemia. Mitoxantrone (less cardiotoxic) can be substituted for these drugs in elderly patients. Etoposide has also been added as a third agent in more refractory or relapsed cases. Vincristine, prednisone, l-asparaginase are used more in acute lymphoid leukemias.
ALL therapy also ... Includes cyclophosphamide, antimetabolite therapies such as 6-tg, 6-mp and methotrexate, and the corticosteroid dexamethasone. Methotrexate and Cytarabine are also administered via an intrathecal route for CNS prophylaxis. There are also many new agents being evaluated in clinical trials. Everyday we are learning more and applying what we learn.