Can you take xenical with tapazole (methimazole)?

No known interaction. There is no known drug interaction between the two medicines and so if needed to be used, they should be ok to take. I assume you are hyperthyroid and thus taking tapzole? Since hyperthyroidism can cause wt loss, i would recommend waiting until your thyroid status is stablized/corrected before taking xenical. Consult with doc. Good luck.