What are the advantages of monoclonal antibodies over normal antiserum?

Specific. Antiserum represents a polyclonal mixture of antibodies that frequently are not tolerated when needed and do not have the same therapeutic effect as a dose of a monoclonal given at 3-4mg./kg. A monoclonal antibody, is a pure antibody obtained from immunized B cells fused with a myeloma cell to give it immortality ( a hybrid Ca or oma cell). It is frequently produced in humanized form.