1 doctor weighed in:

Since neurosteroids are made by glial cells and not endocrine glands, are they considered hormones? Is there a name for non-gland-produced hormones?

1 doctor weighed in
Dr. Philip Kern
Internal Medicine - Endocrinology

In brief: Hormones

The terminology has not really caught up to the research.
"Hormone" usually refers to a substance that is made in one cell/organ but then influences another organ, like thyroxine or cortisol. Neurosteroids act locally in the synapse on neurotransmission, so not a hormone by usual definition. But there are a lot of substances that act locally (eg. prostaglandins, cytokines). What do we call them?

In brief: Hormones

The terminology has not really caught up to the research.
"Hormone" usually refers to a substance that is made in one cell/organ but then influences another organ, like thyroxine or cortisol. Neurosteroids act locally in the synapse on neurotransmission, so not a hormone by usual definition. But there are a lot of substances that act locally (eg. prostaglandins, cytokines). What do we call them?
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