4 doctors weighed in:

I take Epilim Chrono 500mg which isn't actually equal Depakote ER. (500mg Epilim = 333mg sodium valproate + 145 mg valproic acid),so when to test?

4 doctors weighed in
Dr. Eric Weisman
Neurology
2 doctors agree

In brief: Random

The idea is this medication is supposed to generate a steady state level after about 3 days.
Peak and trough levels matter if you are looking for toxicity or sub-therapeutic levels with medications with a short half life. Also Depakote has a very wide therapeutic level (50-100) Consider obtaining a Vit D level (which is often low) and checking ammonia after being on this medication a while.

In brief: Random

The idea is this medication is supposed to generate a steady state level after about 3 days.
Peak and trough levels matter if you are looking for toxicity or sub-therapeutic levels with medications with a short half life. Also Depakote has a very wide therapeutic level (50-100) Consider obtaining a Vit D level (which is often low) and checking ammonia after being on this medication a while.
Dr. Eric Weisman
Dr. Eric Weisman
Thank

In brief: 3 days

Half life of valproate sodium and valproic acid is 16 hours.
Steady state is reached at 3 1/2 half lives--i.e. 62 hours. For ease of calculation, 72 hours would show a steady state. Measure trough level--i.e. just before your next dose schedule.

In brief: 3 days

Half life of valproate sodium and valproic acid is 16 hours.
Steady state is reached at 3 1/2 half lives--i.e. 62 hours. For ease of calculation, 72 hours would show a steady state. Measure trough level--i.e. just before your next dose schedule.
Dr. James Van norman
Dr. James Van norman
Thank
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