Depends on headache. Certain types respond to some drugs rapidly. But Dr. Italia's correct. It's difficult to find "quick" solutions without knowing more info. Best advice at this point is either Tylenol (acetaminophen) as per labeled instructions or Excedrin Migraine if symptoms are severe with nausea/vomiting. Important thing is to see doctor & get workup to prevent next one. Keep track of HA's in diary (found on Internet).