Doxepin cream 5% Topical Doxepin is easy to use & very safe. Sometimes using large amounts causes mild drowsiness. Start using it at bedtime. Use it as often as needed to control pain. Most people begin at 4 times a day and gradually reduce frequency as they improve. This may require 2-4 months or more. About 20% of people become allergic after long use & stop. It is far safer & far more effective than anything el.