Can I take Tylenol (acetaminophen) with a cream made of ketoprofen, baclofen, and lidocaine?

Yes, w/ restrictions. It is safe to take those in combination assuming you do not have significant liver disease or are not a long time heavy drinker. Make sure you read ingredients of all the pills you take as some contain acetaminophen and that is not immediately apparent. Be certain to maintain good hydration and do not exceed 1000 mg of tylenol at one dose or more than 3500 mg in one day. Never over 4000 mg in 24hr.