Can Replens cause cystitis-type symptoms or bladder spasms (urine culture is negative)?

Here are some ... Disregarding the wonderful side effect profile of a drug, you should stop using Replens now; then, wait and see if the described symptoms are tolerable to you and you're getting better slowly but surely day by day. If not resolved as wished and expected, see Doc timely for evaluation, confirmation, and counseling for the future.