3 doctors weighed in:

Pristiq (desvenlafaxine) 50mg taking it before bed as it makes me so tired, can't take it in morning. Wake up still so tired! Should i take it earlier in the night?

3 doctors weighed in
Dr. Mark Fisher
Neurology
2 doctors agree

In brief: Not sure

Desvenlafaxine has a plasma 1/2-life of about 11 hr, so a single dose isn't mostly eliminated for 48-60 hr. However, side effects aren't necessarily dose- or time-dependent.
Sometimes it takes up to a month for some side effects to become tolerable. The doc who prescribed it is obligated to work with you on this and should be willing to anyway if (s)he's a caring practitioner.

In brief: Not sure

Desvenlafaxine has a plasma 1/2-life of about 11 hr, so a single dose isn't mostly eliminated for 48-60 hr. However, side effects aren't necessarily dose- or time-dependent.
Sometimes it takes up to a month for some side effects to become tolerable. The doc who prescribed it is obligated to work with you on this and should be willing to anyway if (s)he's a caring practitioner.
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