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What are the advantages monoclonal antibodies offer over normal antisera?

1 doctor weighed in
Dr. Myron Arlen
Surgery - Oncology

In brief: More effective

Before Milstein developed the concept of monoclonal antibodies derived from a fused B cell with myeloma cell (hybidoma) all antibodies were polyclonal.
They were derived from injecting protein into a horse or cow and extracting the serum which contained antibodies against foreign organisms, and food products. Activity was poor. Monoclonals are now genetically engineered as human and functional

In brief: More effective

Before Milstein developed the concept of monoclonal antibodies derived from a fused B cell with myeloma cell (hybidoma) all antibodies were polyclonal.
They were derived from injecting protein into a horse or cow and extracting the serum which contained antibodies against foreign organisms, and food products. Activity was poor. Monoclonals are now genetically engineered as human and functional
Dr. Myron Arlen
Dr. Myron Arlen
Thank
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