Does culture play a role in the acceptance of congenital abnormalities?

Yes. In Japan, there is a terrible stigma to many birth defects, and even non-defects like being left-handed. Among ignorant people of any kind (and forgive me if saying "ignorant" offends the local multiculturalists), birth defects lead to superstitious fear and often ostracism -- or refusal to get needed corrections ("It's God's punishment.") Having a birth defects is hard enough without all this.