I'm on 10 mg Lexapro (escitalopram) and took an Imitrex also last night for a migraine. Was this safe, because I woke up feeling jittery, dizzy, and hyper.

Imitrex (sumatriptan) Well, you experienced side effects from the Imitrex. In some cases, medications like Lexapro, (escitalopram) can make Migraines worse. For my patients with Migraines, I like to use something Migrelief, which you can order on line and which can prevent Migraines. Also, if you were my patient, I would suggest the next time, trying half of the Imitrex. Do not change anything without checking first with your doctor.