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Doctor has changed medication from Pristiq (desvenlafaxine) to Cymbalta , what is the main difference please and am now more likely to gain weight please. Thank you ?

1 doctor weighed in
Dr. James Eyerman
Psychiatry

In brief: Cymbalta, Pristiq (desvenlafaxine)

Both medications are dual action antidepressants.
At high dose Pristiq (desvenlafaxine) may be a triple action antidepressant. Short term studies show little weight gain in both meds. However individuals vary with regard to side effects as well as their response to a particular antidepressant. Long term studies indicate that similar drugs can cause significant weight gain in susceptible individuals.

In brief: Cymbalta, Pristiq (desvenlafaxine)

Both medications are dual action antidepressants.
At high dose Pristiq (desvenlafaxine) may be a triple action antidepressant. Short term studies show little weight gain in both meds. However individuals vary with regard to side effects as well as their response to a particular antidepressant. Long term studies indicate that similar drugs can cause significant weight gain in susceptible individuals.
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