1 doctor weighed in:

Is tramacet with Zoloft (sertraline) 50mg and amitriptyline 10 mg ok in combination ?

1 doctor weighed in
Dr. Felix Brizuela
Neurology

In brief: In most people

It depends on the individual.
All of that serotonin can put a patient with bipolar disease at risk of a manic episode. If it hasn't happened, it wont. Excess serotonin can cause rapid heart rate, anxiety and shakiness. I personally try to avoid using multiple drugs that work the same, since it can lead to toxic side effects. I like using drugs like abilify (aripiprazole) if I am treating mood disorder

In brief: In most people

It depends on the individual.
All of that serotonin can put a patient with bipolar disease at risk of a manic episode. If it hasn't happened, it wont. Excess serotonin can cause rapid heart rate, anxiety and shakiness. I personally try to avoid using multiple drugs that work the same, since it can lead to toxic side effects. I like using drugs like abilify (aripiprazole) if I am treating mood disorder
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